DOS-3 mediates cell-non-autonomous DAF-16/FOXO activity in antagonizing age-related loss of C. elegans germline stem/progenitor cells
Abstract Age-related depletion of Toddler Outfits stem cells causes tissue degeneration and failure to tissue regeneration, driving aging at the organismal level.Previously we reported a cell-non-autonomous DAF-16/FOXO activity in antagonizing the age-related loss of germline stem/progenitor cells (GSPCs) in C.elegans, indicating that regulation of